Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• findings were also in agreement with the SDS-PAGE results where a gel band of 28 kDa was detected only for silica NPs. Other HDL apolipopoproteins including apoA2 and A4 were also more abundant in the silica nanoparticle corona than the carbon one. In contrast to what was observed for silica, fibrinogen

• incubation in human plasma. b) Densitometry of the gel bands corresponding to fibrinogen and apolipoprotein A1. Abundance of fibrinogen and apolipoprotein A1 in silica and carbon nanoparticle corona at different plasma concentrations. Venn diagrams showing the number of proteins shared by small silica (black

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• . Keywords: cell receptors; drug targeting; endocytosis; nanoparticle corona; nanoparticle uptake; Introduction Nano-sized materials are widely studied in nanomedicine for their potential use as drug carriers, in imaging, and for diagnostic purposes [1][2][3]. Because of their size, they can interact with

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

• Arianna Gennari,
• Julio M. Rios de la Rosa,
• Erwin Hohn,
• Maria Pelliccia,
• Enrique Lallana,
• Roberto Donno,
• Annalisa Tirella and
• Nicola Tirelli

Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250

• mica (left) and height profiles corresponding to the red dashed lines in the images (right). For the templated Chit35/HA nanoparticles two thresholds were used to calculate separately the volume distributions of the nanoparticle corona and core. Please note that the HA corona is even more visible in

Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers

• Dong Ye,
• Mattia Bramini,
• Delyan R. Hristov,
• Sha Wan,
• Anna Salvati,
• Christoffer Åberg and
• Kenneth A. Dawson

Beilstein J. Nanotechnol. 2017, 8, 1396–1406, doi:10.3762/bjnano.8.141

• test SiO2-NP uptake and interactions with the Caco-2 barrier in the presence and absence of a nanoparticle corona. The corona forming on the SiO2-NPs at different concentrations of serum was also characterised (Supporting Information File 1, Figure S4) and results were in agreement with previous